Fig. 3

Edema is the main Indicator of acute rejection in VCA. A Representative images of edema manifestation in face allograft acute rejection i. No rejection (POM21), ii. early rejection (POM 8) and iii. late rejection (POM26). (Images reproduced with permission from [2] © 2019 Mary Ann Liebert, Inc.) B Edema manifestation in hand allograft acute rejection (Images reproduced with permission from [107] © John Wiley & Sons, Inc.) C Skin allograft acute rejection graded based on Banff Scoring System. Normal skin: unaffected skin, GradeI: mild perivascular infiltration, GradeII: mild perivascular infiltration with/without mild epidermal or adnexal involvement. No epidermal dyskeratosis or apoptosis, Grade III: dense inflammation and epidermal involvement with apoptosis, dyskeratosis, and/or keratinolysis, Grade IV: necrotizing acute rejection. necrosis of skin structures. (Images reproduced with permission from [108] © 2013 Ravi Starzl et al.) D Association of clinical signs or subtherapeutic tacrolimus levels with acute rejection episodes. (Image reproduced with permission from [2] © 2019 Mary Ann Liebert)