Fig. 4

Identification of gene modules related to pyroptosis via comprehensive analysis of PPI network and WGCNA. A PPI network was constructed using the STRING database. B PPI network was visualized using Cytoscape software and the relevance level were ranked in different colors. C Twenty-one hub genes and their connections were identified via the MCODE algorithm. D Determination of WGCNA soft threshold. E Gene clustering tree (dendrogram) was obtained by hierarchical clustering of adjacency-based dissimilarity. F The correlation heatmap of gene modules and phenotypes. G The venn diagram showed the genes shared by PPI hub genes and the WGCNA magenta module