Fig. 2

Transcriptomics analysis reveals PVRIG upregulation to be associated with favorable outcomes in cancer. Correlations between PVRIG expression levels and stemness scores, apoptosis pathway’s enrichment scores, enrichment scores of tumor-infiltrating lymphocytes (TILs) (A), and ratios of CD8+/CD4+ regulatory T cells (B) in pan-cancer and in 33 individual cancer types. C Kaplan–Meier survival curves showing better overall survival in higher-PVRIG-expression-level (upper third) than in lower-PVRIG-expression-level (bottom third) cancer patients in pan-cancer and in nine individual cancer types. The Spearman’s correlation coefficients (ρ) and adjusted P values (FDR) are shown in A; the Pearson’s correlation coefficients (r) and FDR are shown in B; and the log-rank test P values are shown in C. *FDR < 0.05; **FDR < 0.01; ***FDR < 0.001; ^nsFDR ≥ 0.05