Ensemble learning model for identifying the hallmark genes of NFκB/TNF signaling pathway in cancers

Table 1 Comparison of functional similarity

BP similarity	Candidate (#)	non-candidate(#)	p-value	Cohen’s d
TNF	0.0685 (2715)	0.0558 (6390)	6.79E-15	0.24
RELA	0.1092 (2692)	0.0994 (6323)	3.21E-07	0.11
NFKB1	0.1056 (2658)	0.1023 (6197)	2.57E-03	0.04
RELB	0.0851 (2671)	0.0831 (6286)	3.11E-02	0.04
REL	0.1599 (2688)	0.1706 (6317)	9.25E-01	− 0.07
NFKB2	0.1680 (2619)	0.1999 (6101)	1.08E-04	− 0.15

BP Biological Processes
(#) represents the number of genes with non-zero similarity, excluding NFκB/TNF hallmark genes
The similarity is evaluated using the Jaccard index, which measures the shared experimentally validated biological processes with the central member genes. The table presents each category's average BP similarity of the (#) genes
The p-values are derived from the Wilcoxon rank-sum test

ISSN: 1479-5876