Fig. 2

Heterogeneity of cell components in ccRCC tissues and its relationship with clinical survival. A Annotation rules of 7 major cell types, including T cells (CD3), macrophages (CD68), B cells (CD20), endothelial cells (CD31), fibroblasts (αSMA), mesenchymal cells (Vim) and tumor cells (Pan-keratin and/or Ecad), respectively. B UMAP maps colored by expression of CD3, CD68, CD20, CD31,αSMA, Vim, Pan-keratin and Ecad showing that cells from 75 ccRCC tissues. Scale bars indicate the normalized expression intensity. C Heatmap showing the 17-marker expression profiles across the 7 major cell types. Scale bar was normalized by z-score. D The proportion of different cell components and the number of 7 major cell types across various ccRCC tissues