Fig. 3

Clinical characteristics of the AD subclasses. A Comparison of gamma-secretase activity between each subclass. B Comparison of beta-secretase activity between each subclass. C Comparison of alpha-secretase activity between each subclass. D Comparison of Braak between each subclass. E Comparison of NFTs between each subclass. F Comparison of pH between each subclass. G Comparison of age between each subclass. H Proportion of sex between each subclass. I Proportion of APOE4 alleles in each subclass. (0 indicates no APOE4 allele, 1 represents one APOE4 allele, and 2 represents two APOE4 alleles). The clinical data of Fig. A–C, H is from GSE106241 (MCA, n = 16; MCB, n = 25; MCC, n = 19). The clinical data of Fig. E, F is from GSE8442201 (MCA, n = 7; MCB, n = 12; MCC, n = 15). The clinical data of Fig. D is from GSE106241 and GSE8442201 (MCA, n = 23; MCB, n = 37; MCC, n = 34). The clinical data of Fig. G, I are from eight merged datasets (MCA, n = 173; MCB, n = 274; MCC, n = 350). Kruskal–Wallis test was used to compare statistical differences