Association of non-high-density lipoprotein cholesterol trajectories with the development of non-alcoholic fatty liver disease: an epidemiological and genome-wide association study

Table 3 Cox proportional hazard regression analysis for incidence of non-alcoholic fatty liver disease, in the different serum non-HDL cholesterol trajectory groups

	Stable group	Increasing group
Total number, n	1269	934
Incident NAFLD case, n	322	344
Follow-up period, person-year	16958.1	12510.7
Incidence rate per 1000 person-year	18.99	27.50
	HR	HR (95% CI)	p
Unadjusted	1 (reference)	1.59 (1.37–1.85)	< 0.0001
Model 1	1 (reference)	1.60 (1.37–1.86)	< 0.0001
Model 2	1 (reference)	1.50 (1.29–1.75)	< 0.0001
Model 3	1 (reference)	1.54 (1.32–1.80)	< 0.0001
Model 4	1 (reference)	1.46 (1.25–1.71)	< 0.0001

Model 1: adjusted for age and sex
Model 2: adjusted for variables included in Model 1, as well as body mass index, smoking status, drinking status, physical activity, and total energy intake
Model 3: adjusted for variables included in Model 2, as well as hypertension, diabetes mellitus, and serum C-reactive protein level
Model 4: adjusted for variables included in Model 3, as well as serum alanine aminotransferase level and triglyceride level
NAFLD, non-alcoholic fatty liver disease; HR, hazard ratio; CI, confidence interval

ISSN: 1479-5876