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Table 1 Baseline characteristics of study population

From: Association of non-high-density lipoprotein cholesterol trajectories with the development of non-alcoholic fatty liver disease: an epidemiological and genome-wide association study

 

Total (n = 2203)

Serum non-HDL cholesterol trajectory groups

p*

Stable (n = 1269)

Increasing (n = 934)

Male sex, n (%)

891 (40.4%)

562 (44.29%)

329 (35.22%)

 < 0.001

Age, years

50.9 ± 8.5

50.7 ± 8.7

51.0 ± 8.2

0.419

BMI, kg/m2

23.4 ± 2.6

23.2 ± 2.7

23.8 ± 2.5

 < 0.001

WC, cm

78.5 ± 7.6

78.0 ± 7.6

79.3 ± 7.6

 < 0.001

MBP, mmHg

92.0 ± 12.1

92.1 ± 12.2

91.9 ± 12.0

0.62

Smoking status, n (%)

   

0.030

Non-smoker

1537 (69.8%)

854 (67.3%)

683 (73.13%)

 

Ex-smoker

277 (12.6%)

176 (13.87%)

101 (10.81%)

 

Intermittent smoker

34 (1.5%)

21 (1.65%)

13 (1.39%)

 

Daily smoker

355 (16.1%)

218 (17.18%)

137 (14.67%)

 

Currently drinking, n (%)

953 (43.3%)

579 (45.63%)

374 (40.04%)

0.010

Physical activity, n (%)

   

 < 0.001

Low

137 (6.2%)

75 (5.91%)

62 (6.64%)

 

Moderate

1394 (63.3%)

754 (59.42%)

640 (68.52%)

 

High

672 (30.5%)

440 (34.67%)

232 (24.84%)

 

Platelet count, 109/L

262.1 ± 59.8

257.1 ± 59.9

269.0 ± 59.1

 < 0.001

FPG, mg/dL

81.7 ± 11.5

82.1 ± 12.0

81.1 ± 10.8

0.037

Insulin, μU/mL

6.4 ± 2.7

6.3 ± 2.7

6.5 ± 2.8

0.288

Total cholesterol, mg/dL

186.4 ± 32.8

176.5 ± 29.7

199.8 ± 32.0

 < 0.001

Triglyceride, mg/dL

125.1 ± 59.0

115.3 ± 53.0

138.3 ± 63.9

 < 0.001

HDL cholesterol, mg/dL

47.0 ± 10.0

47.5 ± 10.2

46.1 ± 9.7

0.001

LDL cholesterol, mg/dL

114.7 ± 29.7

106.1 ± 26.6

126.5 ± 29.5

 < 0.001

eGFR, mL/min/1.73m2

93.4 ± 13.7

93.6 ± 13.9

93.1 ± 13.4

0.455

ALT, U/mL

21.2 ± 8.7

21.3 ± 8.9

21.1 ± 8.2

0.597

CRP, mg/dL

0.11 [0.05;0.19]

0.11 [0.04;0.19]

0.12 [0.05;0.20]

0.175

Total energy intake, kcal/day

1922.1 ± 656.5

1897.8 ± 619.7

1955.1 ± 702.5

0.047

HTN, n (%)

526 (23.9%)

311 (24.51%)

215 (23.02%)

0.448

DM, n (%)

37 (1.7%)

27 (2.13%)

10 (1.07%)

0.082

Dyslipidemia, n (%)

715 (32.5%)

335 (26.4%)

380 (40.69%)

 < 0.001

  1. BMI, body mass index; WC, waist circumference; MBP, mean blood pressure; FPG, fasting plasma glucose; HDL, high-density lipoprotein; LDL, low-density lipoprotein; eGFR, estimated glomerular filtration rate; ALT, alanine aminotransferase; CRP, C-reactive protein; HTN, hypertension, DM; diabetes mellitus
  2. *p value for comparison of the baseline characteristics between participants in the stable trajectory and increasing trajectory groups; Significance was set at p < 0.05
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Journal of Translational Medicine

ISSN: 1479-5876

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