Fig. 4

Forest plot comparing standardized PRS of NAFLD risk for the control, stable non-HDL cholesterol trajectory, and increasing non-HDL cholesterol trajectory groups in the interaction GWAS result. A Model 1, B Model 2, C Model 3, D Model 4. The models differ in the covariates used in the analysis. In Model 1, age and sex were included as confounding variables, PC1 ~ 10. In Model 2, age, sex, BMI, total energy intake, smoking status, drinking status, physical activity variables were used. In Model 3, the variables used in Model 2 plus HTN, DM, and serum CRP level were adjusted. In Model 4, the serum ALT level was further adjusted from Model 3. PRS, polygenic risk score; NAFLD, non-alcoholic fatty liver disease; HDL, high-density lipoprotein; GWAS, genome-wide association study; PC, principal component; BMI, body mass index; HTN, hypertension; DM, diabetes mellitus; CRP, C-reactive protein; ALT, alanine aminotransferase