Table 2 Genes that reached or approached exome-wide significance in the Fuwai DCM HTx cohort
No. of patients in DCM cases (208) | No. of patients in the reference group (568) | CMC | Fp | SkatO | Zeggini | |
|---|---|---|---|---|---|---|
Truncating + nontruncating | ||||||
TTN | 66 | 84 | 3.90E−07 | 3.06E−09 | 9.66E−08 | 3.17E−08 |
FLNC | 32 | 12 | 7.38E−13 | 4.08E−13 | 2.15E−10 | 6.73E−13 |
LMNA | 9 | 3 | 6.35E−05 | 4.25E−06 | 1.44E−05 | 3.07E−05 |
BAG3 | 7 | 0 | 1.05E−05 | 1.59E−05 | 2.64E−05 | 1.05E−05 |
Truncating variants | ||||||
TTN | 39 | 11 | 1.66E−15 | 1.22E−15 | 2.15E−10 | 1.64E−14 |
FLNC | 18 | 0 | 9.24E−13 | 3.98E−12 | 2.23E−10 | 9.24E−13 |
LMNA | 4 | 0 | 1.21E−03 | 2.91E−03 | 5.24E−03 | 1.21E−03 |
BAG3 | 6 | 0 | 3.71E−05 | 5.49E−05 | 8.03E−05 | 3.71E−05 |
Nontruncating variants | ||||||
TTN | 38 | 74 | 5.95E−02 | 8.09E−02 | 1.60E−01 | 7.79E−02 |
FLNC | 16 | 12 | 1.76E−04 | 2.37E−04 | 3.34E−04 | 1.76E−04 |
LMNA | 5 | 3 | 1.06E−02 | 2.23E−03 | 7.19E−03 | 4.44E−03 |
BAG3 | 1 | 0 | 1.22E−01 | 1.22E−01 | 1.22E−01 | 1.22E−01 |