Fig. 7

Reciprocally pro-tumorigenic crosstalk between MFAP5 + fibroblasts and myeloid cells support tumor progression. A Heatmap of COMPLEMENT signal suggest the key role of MFAP5 + fibroblasts in regulating the functions of C1QC + macrophages and other immune cells in tumor. B Heatmap shows dominant senders, receivers, mediators and influencers in COMPLEMENT signals of tumor inferred by network centrality score. C Bar plot shows the contribution of all L-R pairs in tumor COMPLEMENT pathway. D Spatial transcriptomics visualize the C3 expression at spatial tissue architecture. E Dot plot shows the increased signals that tumor-infiltrating myeloid cells could secreted to target MFAP5 + fibroblasts. F Violin plot shows the expression of L-R pairs of EGF signaling pathway between fibroblasts and myeloid cells in normal (red color) or tumor (green color). G Heatmap shows dominant senders, receivers, mediators and influencers in VISFATIN signals of tumor inferred by network centrality score