Fig. 5

Fibroblasts-myeloid cells based regulatory network detect tumor-specific signaling pathways in CRC. A The circle plots show the overview of cell–cell interaction numbers between fibroblasts and myeloid cells in tumor tissues (right) and normal tissues (left) respectively, the broader arrow, the more numbers of interactions. B Bar plot of tumor- or normal- specific signaling pathways between fibroblasts and myeloid cells inferred by CellChat, red color represents the signals that increased in normal tissues, and blue color represents the interactions increased in tumor tissues. C The river plot shows the outgoing communication patterns of certain cells in CRC tissue. D Dot plot of ligand-receptor (L-R) pairs of several tumor-specific pathways between fibroblasts (sources) and myeloid cells (receptors). E Bar plot shows the contribution of all L-R pairs in COLLAGEN pathway within the tumor tissue. F Heatmap shows dominant senders, receivers, mediators and influencers in TGFβ and FN1 signals of tumor inferred by network centrality score