Novel models by machine learning to predict prognosis of breast cancer brain metastases

Li, Chaofan; Liu, Mengjie; Zhang, Yinbin; Wang, Yusheng; Li, Jia; Sun, Shiyu; Liu, Xuanyu; Wu, Huizi; Feng, Cong; Yao, Peizhuo; Jia, Yiwei; Zhang, Yu; Wei, Xinyu; Wu, Fei; Du, Chong; Zhao, Xixi; Zhang, Shuqun; Qu, Jingkun

doi:10.1186/s12967-023-04277-2

Journal of Translational Medicine

Table 5 Comparison of patient characteristics according to surgery treatment before and after propensity score matching (PSM)

From: Novel models by machine learning to predict prognosis of breast cancer brain metastases

Characteristics	Unmatched Cohort					1:1 propensity score matched (PSM) Cohort
	Surgery		Surgery not given		Unadjusted	Surgery		Surgery not given		PSM-adjusted
	N = 234	%	N = 1699	%	P value	N = 200	%	N = 200	%	P value
Age at diagnosis					0.004					0.951
< 40	24	10.26	117	6.89		19	9.50	18	9.00
40–49	41	17.52	210	12.36		34	17.00	32	16.00
50–59	72	30.77	457	26.90		60	30.00	59	29.50
60–69	57	24.36	519	30.55		49	24.50	50	25.00
70–79	23	9.83	284	16.72		23	11.50	29	14.50
80 +	17	7.26	112	6.59		15	7.50	12	6.00
Subtype					< 0.001					0.815
HR + /HER2-	85	36.32	632	37.20		75	37.50	68	34.00
HR + /HER2 +	33	14.10	275	16.19		30	15.00	29	14.50
HR-/HER2 +	29	12.39	210	12.36		26	13.00	29	14.50
HR-/HER2-	64	27.35	269	15.83		48	24.00	46	23.00
Unknown	23	9.83	313	18.42		21	10.50	28	14.00
Race					0.830					0.786
White	172	73.50	1275	75.04		143	71.50	148	74.00
Black	38	16.24	269	15.83		34	17.00	33	16.50
Other	24	10.26	155	9.12		23	11.50	19	9.50
Histological type					< 0.001					0.700
IDC	177	75.64	1082	63.68		149	74.50	149	74.50
ILC	11	4.70	86	5.06		10	5.00	6	3.00
Mixed	12	5.13	58	3.41		10	5.00	9	4.50
Other	34	14.53	473	27.84		31	15.50	36	18.00
Marital status					0.132					0.623
Married	105	44.87	685	40.32		86	43.00	81	40.50
Single	64	27.35	430	25.31		56	28.00	52	26.00
Others	65	27.78	584	34.37		58	29.00	67	33.50
T stage					< 0.001					0.802
T1	34	14.53	162	9.54		25	12.50	28	14.00
T2	69	29.49	343	20.19		53	26.50	48	24.00
T3	31	13.25	217	12.77		29	14.50	23	11.50
T4	84	35.90	556	32.73		77	38.50	86	43.00
Tx	16	6.84	421	24.78		16	8.00	15	7.50
Grade					< 0.001					0.923
Well	9	3.85	58	3.41		8	4.00	7	3.50
Moderately	52	22.22	396	23.31		48	24.00	43	21.50
Poorly	146	62.39	610	35.90		117	58.50	121	60.50
Unknown	27	11.54	635	37.37		27	13.50	29	14.50
Median household income (inflation adjusted)					0.093					0.944
< 40,000$	19	8.12	85	5.00		15	7.50	14	7.00
40,000–49,999$	30	12.82	189	11.12		24	12.00	28	14.00
50,000–59,999$	41	17.52	251	14.77		35	17.50	30	15.00
60,000–69,999$	76	32.48	566	33.31		63	31.50	63	31.50
70,000$ +	68	29.06	608	35.79		63	31.50	65	32.50
Chemotherapy					< 0.001					0.586
No/unknown	66	28.21	812	47.79		63	31.50	58	29.00
Yes	168	71.79	887	52.21		137	68.50	142	71.00
Radiotherapy					< 0.001					0.517
No/unknown	60	25.64	697	41.02		59	29.50	65	32.50
Yes	174	74.36	1002	58.98		141	70.50	135	67.50
Liver metastases					< 0.001					0.370
No/unknown	193	82.48	1096	64.51		159	79.50	166	83.00
Yes	41	17.52	603	35.49		41	20.50	34	17.00
Lung metastases					0.002					0.918
No/unknown	154	65.81	938	55.21		124	62.00	123	61.50
Yes	80	34.19	761	44.79		76	38.00	77	38.50

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ISSN: 1479-5876

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