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Table 2 Univariate and multivariate COX analysis of characteristics extracted from SEER database

From: Novel models by machine learning to predict prognosis of breast cancer brain metastases

 

Univariate COX analysis

Multivariate COX analysis

OS

BCSS

OS

BCSS

HR

95%CI

P Value

HR

95%CI

P Value

HR

95%CI

P Value

HR

95%CI

P Value

Age at diagnosis

 < 40

Reference

  

Reference

  

Reference

  

Reference

  

 40–49

1.292

1.006–1.660

*

1.201

0.922–1.564

0.175

1.322

0.646–2.706

0.444

1.105

0.521–2.279

0.791

 50–59

1.423

1.132–1.788

**

1.371

1.080–1.740

**

2.232

1.180–4.221

*

2.293

1.165–4.101

*

 60–69

1.674

1.336–2.099

***

1.608

1.270–2.037

***

1.900

1.030–3.620

*

1.746

1.002–3.181

*

 70–79

2.291

1.802–2.911

***

2.175

1.692–2.796

***

3.336

1.636–6.805

***

3.737

1.845–7.569

***

 80 + 

2.710

2.056–3.574

***

2.448

1.824–3.286

***

1.908

0.764–4.767

0.166

2.282

1.061–5.617

*

Months from diagnosis to therapy

 0 month

Reference

  

Reference

  

Reference

  

Reference

  

 ≥ 1 month

0.842

0.753–0.942

**

0.846

0.751–0.953

**

0.799

0.580–1.088

0.159

0.782

0.569–1.075

0.128

Subtype

 HR + /HER2-

Reference

  

Reference

  

Reference

  

Reference

  

 HR + /HER2 + 

0.772

0.659–0.904

**

0.790

0.668–0.934

**

0.900

0.559–1.497

0.674

0.860

0.516–1.435

0.564

 HR-/HER2 + 

0.962

0.813–1.138

0.653

0.983

0.822–1.174

0.846

2.163

1.407–3.606

***

2.029

1.251–3.290

**

 HR-/HER2-

1.744

1.511–2.015

***

1.830

1.572–2.129

***

3.575

2.380–5.771

***

3.369

2.150–5.278

***

Race

 White

Reference

  

Reference

  

Reference

  

Reference

  

 Black

1.266

1.107–1.448

***

1.222

1.057–1.412

**

1.002

0.601–1.496

0.994

0.936

0.581–1.510

0.787

 Other

0.883

0.735–1.061

0.185

0.812

0.663–0.993

*

0.824

0.480–1.541

0.519

0.754

0.411–1.382

0.361

Histological type

 IDC

Reference

  

Reference

  

Reference

  

Reference

  

 ILC

0.992

0.779–1.262

0.947

0.955

0.738–1.236

0.728

2.794

1.266–6.197

*

2.838

1.297–6.214

**

 Mixed

0.887

0.679–1.158

0.449

0.857

0.644–1.139

0.287

1.040

0.536–2.027

0.908

0.934

0.468–1.862

0.846

 Other

1.354

1.209–1.516

***

1.225

1.083–1.386

**

1.422

0.784–2.724

0.270

1.015

0.484–2.128

0.970

Marital status

 Married

Reference

  

Reference

  

Reference

  

Reference

  

 Singled

1.262

1.111–1.435

***

1.251

1.091–1.435

**

1.793

1.198–2.695

**

1.879

1.253–2.819

**

 Widow/divorced/other

1.519

1.351–1.706

***

1.531

1.353–1.734

***

1.571

1.034–2.253

*

1.543

1.044–2.279

*

T Stage

 T1

Reference

  

Reference

  

Reference

  

Reference

  

 T2

1.064

0.878–1.291

0.526

1.146

0.931–1.412

0.199

1.839

0.986–3.360

0.051

1.915

0.998–3.650

0.056

 T3

1.137

0.921–1.405

0.233

1.231

0.981–1.545

0.073

1.652

0.784–3.289

0.168

1.543

0.756–3.146

0.233

 T4

1.248

1.042–1.495

*

1.337

1.099–1.626

**

1.918

1.025–3.419

*

1.910

1.023–3.566

*

N Stage

 N0

Reference

  

Reference

  

refereNce

  

Reference

  

 N1

0.934

0.815–1.071

0.327

0.951

0.822–1.100

0.502

0.979

0.646–1.584

0.925

/

/

/

 N2

0.788

0.645–0.963

*

0.834

0.675–1.029

0.09

0.864

0.411–1.702

0.687

/

/

/

 N3

0.921

0.777–1.092

0.342

0.962

0.804–1.152

0.676

1.171

0.718–1.907

0.524

/

/

/

Grade

Well differentiated

Reference

  

Reference

  

Reference

  

Reference

  

 Moderately differentiated

1.175

0.871–1.586

0.291

1.266

0.914–1.754

0.156

0.906

0.423–1.939

0.799

0.820

0.370–1.820

0.626

 Poorly differentiated

1.435

1.072–1.921

*

1.561

1.137–2.145

**

1.140

0.529–2.458

0.738

1.177

0.530–2.618

0.689

Median household income(inflation adjusted)

 < 40,000$

Reference

  

Reference

  

Reference

  

Reference

  

 40,000–49,999$

1.055

0.823–1.352

0.676

1.006

0.774–1.308

0.965

0.559

0.254–1.230

0.148

0.604

0.277–1.320

0.207

 50,000–59,999$

1.053

0.888–1.249

0.477

1.058

0.823–1.361

0.659

0.728

0.357–1.488

0.385

0.733

0.356–1.506

0.398

 60,000–69,999$

0.931

0.805–1.076

0.748

0.936

0.742–1.181

0.579

0.724

0.381–1.377

0.325

0.651

0.341–1.243

0.193

 70,000$ + 

0.760

0.656–0.879

*

0.751

0.595–0.948

*

0.522

0.271–1.006

0.052

0.523

0.273–0.999

*

Chemotherapy

 No/unknown

Reference

  

Reference

  

Reference

  

Reference

  

 Yes

0.454

0.410–0.502

***

0.477

0.428–0.531

***

0.386

0.267–0.558

***

0.436

0.301–0.637

***

Radiotherapy

 No/unknown

Reference

  

Reference

  

Reference

  

Reference

  

 Yes

0.629

0.568–0.697

***

0.667

0.598–0.744

***

0.721

0.499–1.042

0.082

0.753

0.520–1.092

0.135

Surgery

 No/unknown

Reference

  

Reference

  

Reference

  

Reference

  

 Yes

0.619

0.529–0.724

***

0.615

0.520–0.727

***

0.693

0.430–1.117

0.132

0.742

0.464–1.186

0.212

Bone metastases

 No/unknown

Reference

  

Reference

  

Reference

  

Reference

  

 Yes

0.956

0.859–1.063

0.407

1.002

0.894–1.123

0.973

/

/

/

/

/

/

Liver metastases

 No/unknown

Reference

  

Reference

  

Reference

  

Reference

  

 Yes

1.290

1.159–1.436

***

1.283

1.144–1.438

***

1.286

0.892–1.860

0.179

1.264

0.877–1.823

0.209

Lung metastases

 No/unknown

Reference

  

Reference

  

Reference

  

Reference

  

 Yes

1.434

1.294–1.589

***

1.426

1.278–1.592

***

1.606

1.157–2.230

**

1.698

1.219–2.365

**

Distant Lymph nodes metastases

 No/unknown

Reference

  

Reference

  

Reference

  

Reference

  

 Yes

1.128

0.942–1.352

0.190

1.093

0.900–1.327

0.368

/

/

/

/

/

/

Distant other metastases

 No/unknown

Reference

  

Reference

  

Reference

  

Reference

  

 Yes

1.331

1.101–1.609

**

1.322

1.079–1.620

**

1.195

0.829–1.723

0.339

1.216

0.842–1.757

0.296

  1. *P < 0.05,
  2. **P < 0.01,
  3. ***P < 0.001
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Journal of Translational Medicine

ISSN: 1479-5876

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