Clinical, pathological, and comprehensive molecular analysis of the uterine clear cell carcinoma: a retrospective national study from TMRG and GINECO network

Table 6 Summary of most relevant findings

	IHC	aGCH	Gene expression
Main alterations in UCCC vs endometroid cancer	Lower ER expression (13% vs 64%)	Amplifications of 10q22.2 (ADK), 14q24.3 (SNW3), 17q12 (ERBB2), 17q23.1 (VMP1)	Increase expression of genes related to immune response and extra-cellular matrix
	Lower PR expression (8% vs 54%)	Deletions of 4q13.2 (UGT2B17), 20p13 (SIRPB1)	Decrease expression of genes associated with fatty acid metabolism and FGF-related pathways
	Lower PR expression (8% vs 54%)	Higher HRD score
Prognostic alterations	P16 expression	None	Immune cluster based on mRNA unsupervised analysis
Prognostic alterations	HR = 5.88; 95 CI [1.56–25]	None	p = 4.35 E−02, log rank test

IHC immunohistochemistry; aCGH array-comparative genomic hybridization; UCCC uterine clear cell carcinoma; ER estrogen receptor; PR progesteron receptor; HRD homologouis recombination deficiency; HR hazard ratio; 95 CI 95% confidence interval

ISSN: 1479-5876