Fig. 2

Validation of EV-delivered miRNAs as biomarkers for AA and CRC. Relative expression of plasma EV-delivered A miR-185-5p B miR-30d-5p C miR-126-3p D miR-4433b-3p among HD, AA, and CRC patients in Cohort I. E Relative expression of plasma EV-delivered miR-185-5p among HD, AA, and CRC patients in Cohort II. Horizontal lines represent the mean ± SD of data in each group. The expression of each miRNA was normalized relative to the expression of reference miRNA cel-miR-39-3p (C. elegans-specific microRNA mimic as an exogenous control). *, P < 0.05; ***, P < 0.001; NS non-significance