Fig. 2

Hsa_circ_0002348 was upregulated in the placentas of preeclampsia patients. A qRT-PCR analysis of hsa_circ_0002348 expression in the placentas of preeclampsia patients with mild clinical symptoms (n = 22) and severe clinical symptoms (n = 27), compared with normal pregnant controls (n = 42); B representative images of BASEscope in situ hybridization (ISH) showing hsa_circ_0002348 expression in the placentas of preeclampsia patients (n = 3) and normal pregnant controls (n = 3); Scale bar, 50 μm; C correlation analysis of hsa_circ_0002348 expression and SBP, DBP, proteinuria level in preeclampsia patients; circ_0002348 representing hsa_circ_0002348; the data presented as mean ± SEM; *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001; ns not significant, SBP systolic blood pressure, DBP diastolic blood pressure