Targeting GBM with an Oncolytic Picornavirus SVV-001 alone and in combination with fractionated Radiation in a Novel Panel of Orthotopic PDX models

Table 2 Molecular sub-classification of patient and/or PDOX models using two different classification system

Sample ID	500 genes	840 genes	Correlation coefficient	Human cell %
Matched pairs
Pt-K012GBM	Proneural/neural	Proneural/neural	0.56	100
IC-K012GBM-III	Proneural/neural	Proneural/neural		56
Pt-K031GBM	Proneural/neural	Proneural/neural	0.66	99.8
IC-K031GBM-I	Proneural/neural	Proneural/neural		92.8
Pt-K024GBM	Classical	Mesenchymal	0.67	100
IC-K024GBM-III	Classical	Mesenchymal		64
Pt-K060GBM	Classical	Mesenchymal	0.64
IC-K060GBM-I	Classical	Proneural/neural		31.6
Pt-K064GBM	Classical	Mesenchymal	0.63	100
IC-K064GBM-I	Classical	Proneural/neural		n/d
Not matched pairs
Pt-K033GBM	Classical	Mesenchymal	0.64	100
IC-K033GBM-III	Mesenchymal	Classical		51.9
Pt-K035GBM	Classical	Mesenchymal	0.72	100
IC-K035GBM-III	Mesenchymal	Classical		66
Pt-K038GBM	Proneural/neural	Proneural/neural	0.54	100
IC-K038GBM-III	Mesenchymal	Classical		48.1
Pt-K045GBM	Proneural/neural	Proneural/neural	0.54	100
IC-K045GBM-III	Classical	Mesenchymal		82
PDOX model only
IC-A129GBM-I	Classical	Proneural/neural		n/d
IC-A46GBM-III	Proneural/neural	Proneural/neural		50
IC-K014GBM-III	Mesenchymal	Proneural/neural		40
IC-K023GBM-III	Proneural/neural	Proneural/neural		50
IC-V0914-III	Proneural/neural	Proneural/neural		93.7

ISSN: 1479-5876