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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: Targeting GBM with an Oncolytic Picornavirus SVV-001 alone and in combination with fractionated Radiation in a Novel Panel of Orthotopic PDX models

Fig. 5

Time-course immunohistochemical analysis of PDOX tumors treated with SVV-001. The implanted GBM cells from two GBM models IC-A46GBM (A46) and IC-K012GBM (K012) were allowed to grow for 8 weeks to form xenograft tumors before receiving a single tail vein injection of SVV-001 (1 × 1011vp/kg) (top panel) and examined for in vivo SVV-001 (SVV) infection, DNA damage (rH2AX), cell proliferation (Ki67), apoptosis (Caspase 3) as well as human-mitochondria (MT) 24 hr—7 days post SVV-001 administration. An image of H&E staining of IC-K-012GBM (highlighted with red boarder) was included to show the histology of untreated tumor core. (Scale bar: 50 µM)

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Journal of Translational Medicine

ISSN: 1479-5876

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