Fig. 3

Infection and killing of GBM cells by SVV-001 in vitro. a Infection of neurosphere cultures derived from two GBM PDOX models. Tumor cells incubated with SVV-GFP from 20 to 2,000 viral particles/cells for 1 to 7 days were subjected to image detection of GFP+ cells (left panel) followed by quantitative analysis with FCM (right panel). *P<0.05 between the treated groups. b Time-course analysis of cell proliferation by SVV-001 (0.5 vp/cell) for 14 days. Cell viabilities in the treated cells were normalized to the untreated cells