Fig. 8
From: Intraparenchymal convection enhanced delivery of AAV in sheep to treat Mucopolysaccharidosis IIIC
Comparison of HGSNAT expression in AAV9-HGSNAT-treated sheep 3 weeks post-surgery. Vector distribution is represented by three-dimensional schematic drawings of the brain. Each brain was divided into 1cm3 cubes. Quantitative comparison of HGSNAT activity above endogenous background level was assessed (A, C). HGSNAT values were determined as fold increase compared to the mean of 2 un-injected sheep for that relative brain section and VCN in two different sheep O95 and Y242 (C, D)