Fig. 9From: A novel camptothecin derivative, ZBH-01, exhibits superior antitumor efficacy than irinotecan by regulating the cell cycleThe alterative expression of some key proteins related to cell apoptosis and DNA damage in LS174T cells after treatment with ZBH-01, CPT-11, and SN38 (50 nmol/l, 24 h), respectively. A, B The result of western blot showed that ZBH-01 is more efficient than CPT-11 and SN38 in regulating the expression of representative proteins. C Histogram of statistical analysis showed the active caspase-3 level in LS174T cells after treatment with ZBH-01, CPT-11, and SN38 (50 nmol/l, 24 h), respectively. D Representative graph showed the active caspase-3 percentage detected by flow cytometry in LS174T cells. ANOVA & two-tailed t-test, n = 3Back to article page