Fig. 1
Functional enrichment analysis of DEGs in RILI and BIPF model mice. A Volcano plot of the genes in dataset GSE41789. Red dots represent the upregulated genes (up), blue dots represent the downregulated genes (down), and gray dots represent the genes with no significant (ns) changes in the irradiated samples. Adjusted p-value < 0.05 with the threshold |log2(Fold Change)|> 0.585 is considered significant. B Heatmap of top fifty DEGs between irradiated group and its nonirradiated control in the dataset GSE41789 with expression value normalized from – 1–1. C Volcano plot of the genes in the dataset GSE37635. Red dots represent the upregulated genes (up), blue dots represent the downregulated genes (down), and gray dots represent no the genes with no significant (ns) changes in BLM-instillation samples. Adjusted p-value < 0.05 with the threshold |log2(Fold Change)|> 0.585 is considered significant. D Heatmap of the top fifty DEGs between BLM-treated group and its control in the dataset GSE41789 with expression value normalized from – 1–1. E Bubble plot showing the top fifteen KEGG pathways and top five terms in BP, MF and CC, respectively, in GO analysis enriched by the DEGs in the dataset GSE41789. F Bubble plot showing the top fifteen KEGG pathways and top five terms in BP, MF and CC, respectively, in GO analysis enriched by the DEGs in the dataset GSE37635. G Bar plot showing the common KEGG pathways and GOBP pathways enriched by the DEGs in datasets GSE41789 and GSE37635