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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: LINC00963-FOSB-mediated transcription activation of UBE3C enhances radioresistance of breast cancer cells by inducing ubiquitination-dependent protein degradation of TP73

Fig. 6

UBE3C is transcriptionally regulated by FOSB. A transcription factors that can bind to UBE3C promoter predicted in UCSCbrowser; B transcription factors that can bind to UBE3C promoter and the conservative binding sequences obtained from JASPAR; C ChIP-seq data of FOSB (ENCSR918GHT), ZNF302 (ENCSR590IHT), SP1 (ENCSR000BPE), ELK1 (ENCSR623KNM) and FOXF2 (ENCSR445FHB) in a lung cancer cell line A549; D binding of FOSB and UBE3C promoter examined by ChIP-qPCR; E, F RT-qPCR and WB assays for the mRNA (E) and protein (F) expression of FOSB and UBE3C in MDA-MB-231 and SK-BR-3 cells following oe-FOSB transfection. Data are expressed as the mean ± SD. Three repetitions were performed. Differences were analyzed by two-way ANOVA. **p < 0.01, ***p < 0.001

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Journal of Translational Medicine

ISSN: 1479-5876

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