Fig. 2

A Supervised classification of 107 lung adenocarcinomas based on the expression of miR-200 s reveals significant interaction between molecular subtypes and a high correlation with WISP classification. B Immune cell estimation determined by MCPcounter shows an enrichment in lymphocytes for tumors with miR-200-sign-down and an enrichment in myeloid cells for tumors with miR-200-sign-up. C PDL1 expression in clusters I IIA and IIB. D Gene set enrichment analysis (GSEA); tumors are ordered by impregnation of the miR-200-up-signature determined by WISP. Adhesion and cell plasticity, cell cycle, TGFbeta and TP53 and immunity are pathways enriched in tumors with a low proportion of the miR-200-up-signature, corresponding to “more mesenchymal”. E Immune cell estimation determined by MCPcounter shows an enrichment in lymphocytes for tumors with low miR-200-sign-up and an enrichment in myeloid cells for tumors with high miR-200-sign-up. F PD-L1 RNA expression