Fig. 4
Serum metabolome and its relationship with the microbiome in HSCT patients. a Partial least squares-discriminant analysis combined with orthogonal signal correction (OPLS-DA) of samples from the BSI and non-BSI groups. R2X = 0.134; R2Y = 0.849; Q2 = 0.416. b Metabolites’ volcano plot. FC, fold change; VIP, variable importance projection. c Bubble diagram of the KEGG enrichment pathway of the differential metabolites. d Chord diagram of correlation between differential metabolites and top 10 species. The relationships were shown according to correlation coefficient (R) > 0.4 and P values (P) < 0.05. e Two dimensional correlation scatter plot of Klebsiella quasipneumonae (relative abundance) and CDCA (intensity). The student’s t-test was used for data with a homogeneous variance; otherwise, the Mann–Whitney test was used. Multiple groups were compared using one-way ANOVA