Lipid metabolism, BMI and the risk of nonalcoholic fatty liver disease in the general population: evidence from a mediation analysis

Table 4 Mediation analysis for BMI and NAFLD via lipid parameters in the whole population

Mediator	Total effect	Mediation effect	Direct effect	PM (%)	P-value of PM
TC	0.110 (0.097, 0.123)	0.002 (0.001, 0.002)	0.109 (0.095, 0.122)	1.3	< 0.001
TG	0.110 (0.097, 0.123)	0.009 (0.007, 0.012)	0.101 (0.088, 0.114)	8.3	< 0.001
HDL-C	0.110 (0.097, 0.123)	0.006 (0.004, 0.008)	0.105 (0.091, 0.117)	5.4	< 0.001
LDL-C	0.110 (0.097, 0.123)	0.003 (0.002, 0.004)	0.107 (0.094, 0.120)	2.6	< 0.001
Non-HDL-C	0.110 (0.097, 0.123)	0.005 (0.004, 0.007)	0.105 (0.091, 0.118)	4.9	< 0.001
RC	0.110 (0.097, 0.123)	0.012 (0.010, 0.014)	0.098 (0.085, 0.111)	10.8	< 0.001
TC/HDL-C ratio	0.110 (0.097, 0.123)	0.011 (0.009, 0.014)	0.099 (0.086, 0.112)	10.2	< 0.001
TG/HDL-C ratio	0.110 (0.097, 0.123)	0.009 (0.007, 0.011)	0.101 (0.088, 0.114)	8.2	< 0.001
LDL/HDL-C ratio	0.110 (0.097, 0.123)	0.010 (0.008, 0.012)	0.101 (0.087, 0.114)	8.7	< 0.001
Non-HDL-C/HDL-C ratio	0.110 (0.097, 0.123)	0.011 (0.009, 0.014)	0.099 (0.086, 0.112)	10.2	< 0.001
RC/HDL-C ratio	0.110 (0.097, 0.123)	0.013 (0.010, 0.015)	0.098 (0.085, 0.111)	11.4	< 0.001

PM: propotion mediate; other abbreviations as in Table 1
Adjusting variables: sex, age, WC, SBP, DBP, ALT, AST, GGT, FPG, HbA1c, habit of exercise, smoking status and drinking status

ISSN: 1479-5876