Fig. 2From: Tuning CARs: recent advances in modulating chimeric antigen receptor (CAR) T cell activity for improved safety, efficacy, and flexibilityThe action of suicide genes. A Internal suicide gene is an enzyme that changes a non-toxic drug to a toxic compound that triggers apoptosis. B Dimerization with a small drug that causes activation of apoptosis-triggering protein. CID, chemical inducer of dimerization. C Surface suicide receptor or ADCC target triggering apoptosis upon contact with an extracellular drug or antibodyBack to article page