Skip to main content

Table 2 Plasma proteins that differ significantly by diabetes status and their correlation with plasma gelsolin

From: Plasma gelsolin levels are associated with diabetes, sex, race, and poverty

Protein name

Entrez gene symbol

Diabetes

t-test

p-value

Effect size

Correlation (r) with pGSN

Correlation p-value

Anthrax toxin receptor 2

ANTXR2

0.0014

1.0142

0.6038

0.0001

Matrix-remodeling-associated protein 8:Extracellular domain

MXRA8

0.0005

1.0924

0.5692

0.0003

Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A

MGAT51

0.0007

1.0697

0.5655

0.0003

Cartilage oligomeric matrix protein

COMP

0.0007

1.0689

0.5595

0.0004

Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A

MGAT52

0.0005

1.0888

0.5144

0.0013

Histone-lysine N-methyltransferase EHMT2

EHMT2

0.0013

1.0183

0.4649

0.0043

Transmembrane protein 132C:Extracellular domain

TMEM132C

0.0003

1.1285

0.4560

0.0052

Adiponectin

ADIPOQ

0.0001

1.2230

0.4513

0.0057

Brevican core protein

BCAN

0.0007

1.0629

0.4334

0.0083

Vesicular, overexpressed in cancer, prosurvival protein 1

VOPP1

0.0003

1.1278

0.4299

0.0089

Iduronate 2-sulfatase

IDS

0.0015

1.0072

0.4183

0.0111

72 kDa type IV collagenase

MMP2

0.0008

1.0538

0.3861

0.0200

Peptidyl-glycine alpha-amidating monooxygenase

PAM

0.0007

1.0729

0.3625

0.0298

Dihydrolipoyl dehydrogenase, mitochondrial

DLD3

0.0000

1.2480

0.3602

0.0309

1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-1

PLCD1

0.0017

1.0016

0.3599

0.0311

Prosaposin

PSAP

0.0013

1.0460

0.3595

0.0313

Neurogenic locus notch homolog protein 3

NOTCH3

0.0008

1.0683

0.3463

0.0386

Acetylcholinesterase

ACHE

0.0009

1.0424

0.3347

0.0460

Complement C1q tumor necrosis factor-related protein 5

C1QTNF5

0.0015

1.0095

0.3290

0.0501

Calsyntenin-1

CLSTN1

0.0011

1.0411

0.3266

0.0518

Glypican-3

GPC3

0.0016

1.0006

0.3229

0.0548

Protein Wnt-5b

WNT5B

0.0003

1.1235

0.3126

0.0634

Glutathione reductase, mitochondrial

GSR

0.0016

1.0056

0.3006

0.0748

Dihydrolipoyl dehydrogenase, mitochondrial

DLD4

0.0002

1.1495

0.2651

0.1182

Arylsulfatase A

ARSA

0.0007

1.0896

0.2050

0.2304

Dermokine

DMKN

0.0007

1.0638

0.1446

0.4002

Glutathione synthetase

GSS

0.0008

1.0542

0.0459

0.7905

Cyclic AMP-responsive element-binding protein 3-like protein 4

CREB3L4

0.0007

1.0592

− 0.0158

0.9271

Protein phosphatase 1 regulatory subunit 14A

PPP1R14A

0.0006

1.0902

− 0.0782

0.6505

Sulfatase-modifying factor 1

SUMF1

0.0004

1.1168

− 0.0941

0.5853

Ribonuclease 4

RNASE4

0.0001

1.1939

− 0.0970

0.5735

SH2 domain-containing protein 1A

SH2D1A

0.0007

1.0685

− 0.1072

0.5336

Cyclin-dependent kinase 15; EC = 2.7.11.22

CDK15

0.0009

1.0487

− 0.1344

0.4345

Apoptosis-associated speck-like protein containing a CARD

PYCARD

0.0007

1.0588

− 0.1366

0.4270

Protocadherin gamma-C3

PCDHGC3

0.0011

1.0315

− 0.1539

0.3702

Trafficking protein particle complex subunit 3

TRAPPC3

0.0013

1.0145

− 0.1561

0.3631

Ephrin-A1

EFNA1

0.0010

1.0422

− 0.1580

0.3575

Neural proliferation differentiation and control protein 1

NPDC1

0.0007

1.0657

− 0.1769

0.3019

Delta-like protein 1

DLL1

0.0001

1.1820

− 0.1792

0.2956

Guanine nucleotide exchange factor VAV3

VAV3

0.0004

1.1155

− 0.2064

0.2272

Protein FAM3B

FAM3B

0.0010

1.0383

− 0.2271

0.1828

Vascular non-inflammatory molecule 2

VNN2

0.0006

1.0792

− 0.2457

0.1485

Calsequestrin-1

CASQ1

0.0011

1.0292

− 0.2478

0.1450

Protein kinase C gamma type

PRKCG

0.0002

1.1413

− 0.2723

0.1082

Plasma serine protease inhibitor

SERPINA5

0.0014

1.0203

− 0.2972

0.0783

Rho GTPase-activating protein 36

ARHGAP36

0.0000

1.2910

− 0.3037

0.0718

Insulin-like peptide INSL6

INSL6

0.0001

1.1802

− 0.3769

0.0234

  1. SomaScan was used to quantify plasma proteins and a Student’s t-test was used to examine differences between euglycemic and diabetic individuals. Cohen effect size is indicated. Pearson’s correlation (r) and p-value are indicated for the relationships between plasma proteins and pGSN. Proteins significantly correlated with pGSN are indicated in bold. Values are sorted by correlation with high positive values at top
  2. Multiple markers can match to the same target protein and are uniquely identified by sequence numbers. 1. SomaScan seq. 21768.9; . 2. SomaScan seq. 21813.171; 3. SomaScan seq. 10025.1 ; 4. SomaScan seq. 15527.90 
Back to article page

Journal of Translational Medicine

ISSN: 1479-5876

Contact us