Skip to main content

Table 1 Characteristics of study population according to obesity phenotype

From: Metabolically healthy obesity is associated with higher risk of both hyperfiltration and mildly reduced estimated glomerular filtration rate: the role of serum uric acid in a cross-sectional study

Variables

Metabolically healthy

Metabolically unhealthy

P value*

Non-obese (MHNO)

(n = 267)

Obese (MHO)

(n = 152)

Non-obese (MUNO)

(n = 303)

Obese (MUO)

(n = 466)

eGFR (ml/min/1.73 m2)

96.3 ± 15.0

92.8 ± 15.1

92.7 ± 14.5

91.5 ± 15.1a

0.0005

Age (years)

65.8 ± 8.2

67.6 ± 8.4

67.5 ± 8.0

67.1 ± 7.9

0.048

Male, n (%)

85 (31.8)

69 (45.4)

81 (26.7)

164 (35.2)

0.95

BMI (kg/m2)

22.2 ± 1.9

27.3 ± 2.1a

23.0 ± 1.5a,b

28.1 ± 2.8a,b,c

 < 0.0001

Lifestyle factors

     

 Current smokers, n (%)

35 (13.1)

29 (19.1)

28 (9.2)b

56 (12.0)

0.24

 Current drinkers, n (%)

9 (3.4)

16 (10.5)a

8 (2.6)b

30 (6.4)

0.40

 High physical activity, n (%)

160 (59.9)

90 (59.2)

186 (61.4)

264 (56.7)

0.41

Blood pressure (mmHg)

     

 SBP

127 ± 14

132 ± 14a

136 ± 14a

138 ± 13a,b

 < 0.0001

 DBP

81 ± 8

82 ± 9

83 ± 8

85 ± 8a,b,c

 < 0.0001

Lipid profiles (mmol/L)

     

 TC

5.26 ± 0.89

5.08 ± 0.96

5.16 ± 1.01

5.04 ± 1.00

0.026

 HDL-c

1.57 ± 0.31

1.43 ± 0.25a

1.29 ± 0.28a,b

1.23 ± 0.24 a,b,c

 < 0.0001

 LDL-c

2.79 ± 0.68

2.70 ± 0.71

2.74 ± 0.69

2.67 ± 0.66

0.096

 TG

1.15 (0.89–1.45)

1.34 (1.05–1.51)

1.86 (1.41–2.43)a,b

1.98 (1.52–2.61) a,b

 < 0.0001

Liver enzymes (U/L)

     

 AST

22.0 (19.0–26.0)

22.0 (20.0–27.0)

22.0 (19.0–27.0)

24.0 (19.0–29.0)

0.012

 ALT

16.0 (13.0–22.0)

18.0 (14.0–23.0)

18.0 (14.0–24.0)

22.0 (16.0–31.0)a,c

 < 0.0001

 GGT

17.0 (13.0–25.0)

19.0 (15.0–28.0)

18.0 (15.0–29.0)

24.5 (18.0–33.0)a

0.004

 FPG (mmol/L)

4.87 (4.49–5.44)

5.16 (4.63–5.60)

6.13 (4.99–7.95) a,b

6.37 (5.22–7.38)a,b

 < 0.0001

 Serum uric acid (μmol/L)

278 ± 65

308 ± 79a

292 ± 64

321 ± 71a,c

 < 0.0001

  1. Data were presented as means ± SD for median (interquartile ranges) for continuous variables, and numbers (proportions) for categorical variables
  2. eGFR estimated glomerular filtration rate; BMI body mass index; SBP systolic blood pressure; DBP diastolic blood pressure; TC total cholesterol; HDL-c high-density lipoprotein cholesterol; LDL-c low-density lipoprotein cholesterol; TG triglyceride; AST aspartate aminotransferase; ALT alanine aminotransferase; GGT γ-glutamyltransferase; FPG fasting plasma glucose
  3. *ANOVA for continuous variables and Chi-square test for categorical variables were used to assess the differences among the four groups
  4. aCompared with MHNO, P < 0.05 calculated by Bonferroni test
  5. bCompared with MHO, P < 0.05 calculated by Bonferroni test
  6. cCompared with MUNO, P < 0.05 calculated by Bonferroni test
Back to article page

Journal of Translational Medicine

ISSN: 1479-5876

Contact us