Table 1 The main functions of ROBO and SLIT genes
Gene | Gene_name | HGNC ID | GeneRIF: Gene Reference into Function from NCBI |
|---|---|---|---|
ROBO1 | Roundabout guidance receptor 1 | HGNC:10249 | Aortic valve development, axon guidance, axonogenesis, brain and heart development |
ROBO2 | Roundabout guidance receptor 2 | HGNC:10250 | Aortic valve development, apoptotic process involved in development, axon guidance, axonogenesis, brain and heart development, female gonad development, female sex differentiation |
ROBO3 | Roundabout guidance receptor 3 | HGNC:13433 | Axon guidance, axonogenesis, cell recognition, cell–cell adhesion via plasma-membrane adhesion molecules, neuron projection guidance, neuron recognition |
ROBO4 | Roundabout guidance receptor 4 | HGNC:17985 | Axonogenesis, cell recognition, cell–cell adhesion via plasma-membrane adhesion molecules, neuron projection guidance, neuron recognition |
SLIT1 | Slit guidance ligand 1 | HGNC:11085 | Axon extension, axon guidance, axonogenesis, brain development, central nervous system neuron development |
SLIT2 | Slit guidance ligand 2 | HGNC:11086 | Actin filament polymerization, aortic valve development, apoptotic process involved in development, axon extension, axon guidance, axonogene sis, brain development |
SLIT3 | Slit guidance ligand 3 | HGNC:11087 | Aortic valve development, apoptotic process involved in development, axon extension, axon guidance, axonogenesis, brain development, cardiac chamber development and morphogenesis |