Characteristic | Univariate analysis | Multivariate analysis | ||
---|---|---|---|---|
HR (95% CI) | P value | HR (95% CI) | P value | |
AJCC stage | 1.364 (1.052–1.769) | 0.019 |  |  |
N status | 1.706 (1.229–2.368) | 0.001 | 1.453 (1.022–2.065) | 0.037 |
Lauren’s classification | 0.958(0.648–1.416) | 0.829 |  |  |
IMs expressed on CD8+T cells in TIME | ||||
 CD8+TILs density | 0.995 (0.990–1.000) | 0.064 |  |  |
 PD-1 density | 1.000 (0.994–1.007) | 0.944 |  |  |
 PD-1+CD8+TILs density | 1.001 (0.992–1.010) | 0.862 |  |  |
 PD-1+CD8+TILs (%) | 4.586 (1.654–12.717) | 0.003 | 5.857 (1.915–17.919) | 0.002 |
 TIM-3 density | 1.006 (0.993–1.019) | 0.368 |  |  |
 TIM-3+CD8+TILs density | 1.098 (0.949–1.270) | 0.208 |  |  |
 TIM-3+CD8+TILs (%) | 6.819 (1.990–23.365) | 0.002 |  |  |
 PD-L1 density | 0.999 (0.995–1.004) | 0.818 |  |  |
 PD-L1+CD8+TILs density | 1.744 (1.183–2.572) | 0.005 |  |  |
 PD-L1+CD8+TILs (%) | 10.933(3.608–33.128) |  < 0.001 | 12.410 (3.885–39.639) |  < 0.001 |
Immune cells in TIME | ||||
 CD3+ TILs density | 0.999 (0.997–1.001) | 0.492 |  |  |
 CD8+ TILs density | 0.995 (0.990–1.000) | 0.064 |  |  |
 CD8 to CD3 ratio | 0.031 (0.002–0.521) | 0.016 | 0.128 (0.029–0.566) | 0.007 |
 CD45RO+ TILs density | 0.999 (0.997–1.001) | 0.307 |  |  |
 CD11c+ cells density | 0.929 (0.810–1.065) | 0.290 |  |  |
 CD20+ cells density | 0.981 (0.898–1.071) | 0.665 |  |  |
 CD68+ cells density | 1.033 (0.972–1.097) | 0.295 |  |  |
 CD163+ cells density | 1.085 (0.985–1.196) | 0.099 |  |  |
 CD163 to CD68 ratio | 3.215 (0.747–13.839) | 0.117 |  |  |
 Foxp3+ Tregs density | 0.538 (0.273–1.061) | 0.074 |  |  |