Table 2 Differentially expressed genes between long- and short-term survivors with potential therapeutic targeted drugs
Symbol | Entrez gene name | Fold Change (long/short) | p-value | Short-term mean expression (TPM) | Long-term mean expression (TPM) | Location | Type(s) | Drug(s) |
|---|---|---|---|---|---|---|---|---|
RKCG | Protein kinase C gamma | − 4.82 | 0.01 | 3.86 | 0.77 | Cytoplasm | Kinase | Go6983, ingenol mebutate, Ro31-8220 |
VAMP1 | Vesicle associated membrane protein 1 | − 1.97 | 0.00017 | 15.31 | 7.77 | Cytoplasm | Transporter | Botulinum toxin type B |
PER1 | Period circadian regulator 1 | − 1.82 | 0.0087 | 79.62 | 43.96 | Nucleus | Transcription regulator | Avibactam |
MKNK1 | MAPK interacting serine/threonine kinase 1 | − 1.75 | 0.0081 | 10.27 | 5.89 | Cytoplasm | Kinase | BAY1143269, dacomitinib, ETC-1907206, QL-X-138, SEL201, tomivosertib |
RPS6KA1 | Ribosomal protein S6 kinase A1 | − 1.7 | 0.0022 | 25.9 | 15.24 | Cytoplasm | Kinase | LJH685, PMD-026 |
POLE | DNA polymerase epsilon, catalytic subunit | − 1.59 | 0.01 | 11.9 | 7.53 | Nucleus | Enzyme | Bortezomib/cladribine/rituximabcin interferon |
HIF1A | Hypoxia inducible factor 1 subunit alpha | 1.96 | 0.0083 | 62.38 | 122.14 | Nucleus | Transcription regulator | EZN 2968, PX 478 |
SLC1A1 | Solute carrier family 1 member 1 | 3.86 | 0.01 | 1.18 | 4.54 | Plasma Membrane | Transporter | Riluzole |