Fig. 7

Crosstalk between malignant WM cells and immune cells in WM. A Network plot displaying the capacity for intercellular communication between malignant WM cells and NK, CD8⁺ T cells in 4 phases (top). The line thickness indicating the capacity for intercellular communication. The number of statistically significant ligand-receptor interactions between cell types are provided in the figure. Bar chart showing the number of significant ligand-receptor pairs in malignant WM cells and NK, CD8⁺ T cells in WM samples (bottom). Cell types are labeled by colors. B Venn plots illustrating the common and specific significant ligand-receptor pairs between malignant WM cells and NK, CD8⁺ T cells of 4 phases in WM patients. C Bubble plots showing molecular interaction states of 20 common ligand-receptor pairs (rows) between malignant WM cells and NK, CD8⁺ T cells in 4 phases (5 panels) in WM patients. Columns labeled by colors represent 3 main malignant WM cell subpopulations. D Bubble plots showing molecular interaction states of 27 ligand-receptor pairs (rows) specific to one immune cell between malignant WM cells and NK, CD8⁺ T cells in 4 phases (5 panels) in WM patients. Columns represent 3 main malignant WM cell subpopulations. Dot sizes and colors represent logarithmically transformed P values (Permutation test) and mean expression of interacting molecules in corresponding cell subsets. Molecules in big dots indicate that they were significant in WM cells or immune cells