Fig. 4

Distinct NK cells in WM from HD. A t-SNE projections of subclustered NK cells, labeled in different colors. Cell type annotations are provided in the figure. B Violin plots showing the expression of marker genes in each subtype of NK cells. C The t-SNE plots, showing the distinct distribution of NK cells in HD and WM (left). Boxplots illustrating the fraction of NK subtypes in HD and WM (right). Statistical analysis is an unpaired Wilcoxon test between HDs and WM patients. D t-SNE plots (left) and violin plots (right) illustrating the expression scores for genes related to cytotoxic factors, activating receptors, and inhibitory receptors of NK cells in HD and WM. Unpaired Wilcoxon tests were done between HDs and WM patients. ns: not significant, *P < 0.05, **P < 0.01, ***P < 0.001