Fig. 8

Illustration on the critical role of C/EBPβ-Clec7a axis in neuropathic pain progression, which supports the idea that CCI-induced overexpression of Clec7a, and the direct interaction between C/EBPβ and Clec7a observed along the pain pathways may contribute to neuropathic pain by triggering the phosphorylation of Syk, ERK and JNK proteins, as well as activating NLRP3 inflammasome-mediated pyroptosis