Fig. 2

The expression characteristics of molecules involved in the Clec7a-mediated pathway in spinal cord of the chronic constriction injury rats. A Pearson correlation analysis between Clec7a mRNA and Cebpb, Nlrp3, Gsdmd, Il1b, Il18, CASP1 expression according to the RNA-seq data (n = 4 rats/group). B Representative images and quantitative analysis of co-localization of Iba-1, GFAP or NeuN with NLRP3 in the ipsilateral spinal dorsal horns between Sham and CCI rats (n = 3 rats/group, 1 section/rat, 3 fields of view/section). White arrows point to Clec7a-positive cells. Scale bar: 20 μm. Data are presented as mean ± SEM. Unpaired Student’s t test was used to analyze data between the two groups. *P < 0.05, ***P < 0.001 compared with Sham group