From: Apparent mineralocorticoid excess: comprehensive overview of molecular genetics
 | Classic AME | Non-classic AME |
---|---|---|
Phenotypes | Â | Â |
Range of age at diagnosis | Infant to juvenile | Adolescent to adult |
Blood pressure | III grade hypertension or higher | Normal /mild hypertension |
History of polyuria and polydipsia | Y | N |
Pre- and postnatal growth failure | Y | N |
Failure to survive | Y | N |
Markers | Â | Â |
Electrolyte | Hypokalemia | Normal |
Plasma renin activity | Low | Low |
Plasma aldosterone level | Low | Normal |
Urinary F/E | High | Slightly increased |
Urinary THF + allo-THF/THE | High | Normal/slightly increased |
Others | Exosomal urinary HSD11B2 mRNA | Microalbuminuria, plasminogen activator inhibitor-1, sensitivity c-reactive protein, L-dopachrome, gamma-L-glutamyl-L-methionine sulfoxide, 5-sulfoxymethylfurfural, S-phenylmercapturic acid, bilirubin, L-iditol, deoxyribose 1-phosphate, citric acid TNF |