Table 2 Dutch Lipid Clinic Network criteria as modified and used in this study
From: Assessing the genetic burden of familial hypercholesterolemia in a large middle eastern biobank
Dutch Lipid Clinic Network (DLCN) | Points | No. of QBB participants (n=6140) |
|---|---|---|
Family History | ||
First-degree relative with known coronary and vascular disease | 1 | 862 |
Clinical history | ||
Patient with premature* coronary artery disease | 2 | 50 |
Patient with premature* cerebral or peripheral vascular disease | 1 | 6 |
LDL-C (mmol/liter) | ||
LDL-C (≥ 8.5) | 8 | 28 |
LDL-C (6.5–8.4) | 5 | 75 |
LDL-C (5.0–6.4) | 3 | 264 |
LDL-C (4.0–4.9) | 1 | 801 |
Diagnosis | ||
Definite FH | > 8 | 8 |
Probable FH | 6 – 8 | 41 |
Possible FH | 3 – 5 | 334 |
Unlikely FH | <3 | 5757 |