Fig. 4

Inhibition of ANXA2 relieved pyroptosis and fibrosis in LPS-treated hepatocytes. (A) WB for detecting the effects from LPS treatment and sh-Anxa2 transfection on the expression of ANXA2 and pyroptosis-related proteins (ASC, pro-Caspase1, C-Caspase1, GSDMD, GSDMD-N, and α-SM) in hepatocytes. (B) The contents of ALT, AST, IL-1β, and CRP released by the hepatocytes after LPS treatment and sh-Anxa2 transfection. All cellular experiments were independently repeated three times. **: P < 0.01; ***: P < 0.001