Fig. 5

Gene regulatory network prediction and trajectory analysis. A Heatmap of macrophage-related regulons in different states. Top 5 regulons of macrophage in B health, C hepatitis, D cirrhosis, and E cancer. F Heatmap of naïve CD4 + T cell-related regulons in different states. Top 5 regulons of naïve CD4 + T cells in G health, H hepatitis, I cirrhosis, and J cancer. K Developmental trajectory of Treg cells and naïve CD4 + T cells in four different states inferred by PAGA, colored by cell types and pseudotime, respectively. Note: dpt means diffusion pseudo time. The scale represents the predictive differentiation trajectory. The higher value represents the degree of differentiation