Table 2 Characteristics of melanoma patients and normal subject controls of the independent internal validation cohort

Gender

 Male

13(65%)^a

11 (61,1%)^a

 Female

7 (35%)^a

7 (38,9%)^a

Age (range)

 Male

58(43-79)^b

58 (41-67)^b

 Female

48 (20-67)^b

53 (21-65)^b

BRAF status

 Mutated

8 (40%)^a

–

 Wild-type

8 (40%)^a

 Unknown

4 (20%)^a

M stage

 M1c

20 (100%)^a

Number of brain lesions

 1

7 (35%)^a

–

 2

5 (25%)^a

 3

5 (25%)^a

 >3

3 (15%)^a

Previous local treatments for brain metastases

 Surgery

5 (25%)^a

–

 Radiotherapy

2 (10%)^a

LDH

–

 ≤ULN

15 (75%)^a

 >ULN

5 (25%)^a