Fig. 1

Cellular landscape of CRC in the SMC cohort. A UMAP plot of 57,557 cells in the SMC cohort colored by cell cluster, CMS and tissue type (tumor or normal). Each dot represents a cell and cellular cluster is annotated with text. B. Heatmap of representative markers of cell clusters. A total of 100 random cells in each cluster were chosen for visualization. Marker genes could also be found in Additional file 2: Table S2. The color legend is as in C. C. Proportions of the identified cell clusters across tumor and adjacent normal tissues with relative cell type proportions and total cell numbers. Upper: all cell clusters; bottom: immune and stromal cell clusters. D. Frequencies of selected cell types for tumor and adjacent normal samples. The Wilcoxon rank-sum test p value is shown