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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: Evidence of pyroptosis and ferroptosis extensively involved in autoimmune diseases at the single-cell transcriptome level

Fig. 3

Pyroptosis and ferroptosis drive the melanocyte destruction. (A) Box plot showing pyroptosis geneset score of melanocytes within skin of patients with vitiligo and healthy donor skin. (B) Dot plot showing the expression levels of CASP1, CASP4, CASP6, CASP8, GSDMD, GSDMA, GSDMB, and GSDMC within melanocytes derived from vitiligo groups and control groups. (C) Quantification of ferroptosis suppressor geneset score within melanocytes derived from vitiligo groups and control groups. (D) Dot plot showing the expression levels of ferroptosis-resistant genes (GPX4, NR4A1, FTH1, FTL, MT1G, NFE2L2, and SLC40A1) within melanocytes. (E) Schematic depiction of cell fate of melanocytes under pathological condition

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Journal of Translational Medicine

ISSN: 1479-5876

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