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Fig. 8 | Journal of Translational Medicine

Fig. 8

From: Asprosin inhibits macrophage lipid accumulation and reduces atherosclerotic burden by up-regulating ABCA1 and ABCG1 expression via the p38/Elk-1 pathway

Fig. 8

A model describing the mechanism for asprosin-induced atheroprotection. Asprosin activates p38 and then phosphorylates Elk-1 at Ser383. After phosphorylation, Elk-1 enters the nucleus to stimulate ABCA1 and ABCG1 transcription. Increased ABCA1 and ABCG1 expression promotes cholesterol efflux from macrophages, leading to acceleration of RCT and alleviation of atherosclerotic plaque burden

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Journal of Translational Medicine

ISSN: 1479-5876

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