Fig. 5

The pan-cancer analysis of clonality of driver genes. A The fraction of samples of each cancer type with subclonal (blue circles; left panel) and clonal (red squares; right panel). Drive genes with 5 or more mutations are shown. B Significant enrichment of driver genes with clonal and subclonal mutations. The names of driver genes significantly enriched with clonal (dark blue) or subclonal (light blue) alterations in each cancer are labeled in red stars. C Survival analysis of driver genes with clonal or subclonal mutations in at least two patient. Circles and triangles represent driver genes with clonal mutations and those with both types of mutations, respectively