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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: Extracellular vesicle miR-32 derived from macrophage promotes arterial calcification in mice with type 2 diabetes via inhibiting VSMC autophagy

Fig. 5

MEF2D regulates VSMC autophagy via cGMP-PKG signaling pathway. A Co-IP separated the interaction protein of MEF2D and identified by MS. B KEGG analyzed the signaling pathway of MEF2D interaction protein. C Transcriptome sequencing and KEGG analyzed the signaling pathway of macrophage regulated VSMC osteogenic differentiation. D Venn diagram analyzed the major protein of MEF2D regulated in cGMP-PKG signaling pathway. E The expression of Atp2a and Kcnma1 in VSMC after RAW264.7 treated. F, G The expression of Atp2a3 and Kcnma1 in VSMC after treated with si-Mef2d (F), or pDoubleEx-MEF2D (G). The experiment was repeated 3 times (n = 3), *p < 0.05 and **p < 0.01. Data was shown as means ± s.e.m

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Journal of Translational Medicine

ISSN: 1479-5876

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