Fig. 6

TIGIT/CD155 inhibited the growth of transplanted cervical tumours and the function of CD8⁺ T lymphocytes in C57BL/6 mice. A The CD155 knockout efficiency in U14 cells compared with that of the control group. B Analysis of tumour progression in mice that were injected with U14-NC-CD155 and U14-KO-CD155 cells. C WT-U14 cell-transplanted mice were treated with PD-1 blocking antibodies, TIGIT blocking antibodies or the isotype control. Analysis of tumour progression in mice that received different treatments. D IHC analysis of CD8⁺ T cell infiltration level in tumors in mice received U14-NC-CD155 and U14-KO-CD155 cells. E IHC analysis of CD8⁺ T cell infiltration levels in tumours from mice that received different treatments. F CD8⁺ T cells were isolated from mouse tumour tissues. The levels of TNF-α and IFN-γ secreted by CD8⁺ T cells in mice that received U14-NC-CD155 and U14-KO-CD155 cells were measured. G The levels of TNF-α and IFN-γ secreted by CD8⁺ T cells in mice that received different treatments were measured