Fig. 6

Comparison of the mutational landscape of pancreatobiliary-type AAC with those of PAC and cholangiocarcinoma. A Oncoplot summary of the top 50 most frequently mutated genes in pancreatobiliary-type AAC. B, C oncoplot summary of the same 50 genes in PAC and cholangiocarcinoma. D, E Paired bar charts of the mutation frequency of the 50 genes for a more intuitive comparison. F Fisher’s exact test after multiple test correction identified 34 genes with significantly different mutation frequency between pancreatobiliary-type AAC and cholangiocarcinoma, while only 2 genes were identified between pancreatobiliary-type AAC and PAC. The mutation analysis showed that the mutation landscape of pancreatobiliary-type AAC is similar to that of PAC but different from that of cholangiocarcinoma. AAC, ampullary adenocarcinoma; CHOL, cholangiocarcinoma; PAC, pancreatic adenocarcinoma