Fig. 4

Associations of 5FU-induced expression of gene category scores with tumor relapse and disease-free survival. A Association of 5FU-induced expression of (i) proliferation, (ii) EMT, (iii) differentiation and (iv) pluripotency scores with tumor relapse in colorectal cancer patients. Gene category scores were calculated by averaging the expression of gene markers in individual patients. Proliferation category includes MKI67, CCNA2, CCNB1, CCNB2. EMT category includes SNAIL, FOSL1, ID1. Differentiation category includes EPCAM, CDH1, CK8, CK18. Pluripotency category includes POU5F1, NANOG. Mean ± SD (n = 65 no relapse, n = 20 relapse). *p < 0.05, **p < 0.01, Mann–Whitney U test. B Univariate Kaplan–Meier modeling of associations of 5FU-induced expression of (i) proliferation, (ii) EMT, (iii) differentiation and (iv) pluripotency scores with disease free survival (events are defined as relapse or death by colorectal cancer)